Cerebral hemorrhage after the consumption of amphetamine

Cerebral hemorrhages are rare complications that occur after the consumption of amphetamine; the mortality rate is estimated at 50 %. It is assumed that cerebral hemorrhages are caused by amphetamine-induced hypertensive crises coinciding with pre-existing vascular alterations (congenital vascular malformations, vasculitis). In the present case report, a 40-year-old man, who is said to have regularly consumed hashish, heroin and speed, died of a massive cerebral hemorrhage located in the region of the basal ganglia shortly after the intravenous administration of amphetamine and heroin. In the course of the post-mortem investigation, neither vascular malformations nor vasculitis could be detected in the brain. Even if the evidence for the existence of such alterations was missing, this does not exclude their presence for certain. Other potential amphetamine-induced vascular alterations are discussed.     

Serum cannabinoid levels 24 to 48 hours after cannabis smoking

Low concentrations of THC and 11-hydroxy-THC in serum samples are often claimed not to result from recent cannabis use. Prediction of time of exposure is difficult, especially if distinctive features of drug use could not be observed. Therefore, the aim of the study was to investigate the presence of THC and 11-hydroxy-THC in serum samples as well as to obtain preliminary data on the analyte profile for a time window of 24-48 hours after discontinuation of cannabis smoking. Serum samples from heavy (n = 12, > 1 joint/day), moderate (n = 11, < or = 1 joint/day) and light (n = 6, < 1 joint/week) smokers of cannabis were analyzed for THC, 11-hydroxy-THC and free THC-COOH by GC/MS as well as for glucuronidated THC-COOH by LC/MS-MS. The blood samples were collected 24-48 hours after abstaining from cannabis use. Additionally, 8 specimens were obtained from persons after discontinuation of the drug for more than 48 hours. During collection of the blood samples, distinctive effects due to drug use could not be observed. For heavy users of cannabis, THC was detectable in 8 samples, and in 5 cases both biologically active compounds, THC and 11-hydroxy-THC, were present (1.3-6.4 ng THC/mL serum, 0.5-2.4 ng 11-hydroxy-THC/mL serum). Among moderate users, in 1 sample 1.8 ng THC/mL serum and 1.3 ng 11-hydroxy-THC/mL serum were determined, and another sample was tested positive with low concentrations close to the limit of detection. In serum samples of light users both analytes could not be detected, indicating that in those persons a positive finding of THC and 11-hydroxy-THC may rather result from recent consumption than from cannabis use 1 or 2 days prior to blood sampling. The concentrations of THC-COOH and its glucuronide covered a wide range in all groups of cannabis users. However, there was a trend to higher concentrations in heavy users compared to moderate users, and the mean concentration was smaller in light smokers than in moderate smokers. Overall, the findings indicated that data from pharmacokinetic studies should be supplemented by data obtained from "real-life" samples.     

Return to Europe – A double-edged sword for notaries? The case of Poland and Hungary

Using Poland as a case study, the Polish sociologist Piotr Sztompka has demonstrated most persuasively the significance of trust (and distrust) as a key to the analysis and understanding of socio-political and socio-cultural developments in Central Europe in the transition to democracy. Sztompka's study ends upbeat with a brief glance at the situation in the late 1990s. Had the book been written a decade later, it would have revealed that the path ahead has remained rocky. Public trust in governments, politicians and public institutions generally has remained a scarce commodity.It is against this background that the restoration of an independent civil law notariat, as an integral part of the ‘return to Europe’ project, has occurred in Poland, and, mutatis mutandis, in other Central European countries. However, following a first decade of successful transformation from state employment to liberal profession, notaries in Central Europe now find that it is precisely because they have embraced the status of Western-style liberal professionals that they are coming under attack by both the European Commission and their own national governments. As a result, they have had to embark on a process of reconsideration of their position in order to ensure the profession's survival. This paper traces and compares developments in Poland and Hungary. As can be expected there is a strong common denominator between them. But equally and more interestingly, there are distinctive national features which now, as ‘bloc history’ recedes, are coming increasingly to the fore.     

Discretion and corruption: The Chilean judiciary

Corruption in the judiciary and its effects on the budget of that branch of government, the efficiency of justice (prompt or belated) and its quality (biased or impartial) are analyzed. The discretionary powers of the Supreme Court and those granted to judges to manage their courts, calendar and case load, and the hierarchical administrative structures of judiciaries, which function as a queueing system, may be used as a tool to maximize graft. These phenomena reveal links between institutional forms and incentives. Using the case of Chile and the exceptional emergence of corruption within the judiciary during the military dictatorship, the role of democracy as a punishing and preventive mechanism is highlighted.This article was written while the author was a Senior Fellow at the Orville Schell, Center for International Human Rights Law at Yale Law School, and under the auspices of the North-South Center of the University of Miami.     

Pregabalin--a drug with abuse potential?

A case of pregabalin misuse associated with delusional ideas in a drug addict is reported. Pregabalin has been approved as an adjunct therapy for epilepsy, but also for neuropathic pain and generalized anxiety disorders and is widely used today. It has also been used in clinical trials to study its potential utility as a treatment for tobacco, alcohol and benzodiazepine addiction. Web sites, case reports and an epidemiological study (Swedish National Register of Adverse Drug Reactions) suggest that the drug may be abused, especially by substance-dependent individuals. Pregabalin was analyzed by LC/MS/MS following precipitation of serum proteins. Vigabatrin was used as internal standard. The concentration of 25 pg pregabalin/mL serum determined in the present case is the second highest value published so far after misuse of the substance. Due to paradoxical agitation, anxiety attacks and abnormal thinking, the man was exculpated. Further studies are required to assess the actual abuse potential of pregabalin.     

The study of legislative committees*

ABSTRACT

Proving that legislative committees really matter is not simple. The assembled papers aim to demonstrate fruitful paths to analysing when committees influence policy, what they can and should do, and how to detect their importance to the political process.     

Gender,Ethnicity, and Education as Privileges: Exploring the Generalizability of the Existential Guilt Reaction

Two cross-sectional questionnaire studies were conducted to replicate and extend previous research on the existential guilt reaction. In Study I, gender was considered as a privilege. Male student participants (N = 141) were confronted with the low proportion of women in high-ranking positions and asked to appraise this situation. Self-reported behavior, behavioral intentions, and appeal to authorities aimed at advancing equal opportunities for both genders served as criterion variables. Path analyses were performed to explore the correlation structure among the variables. Self-reported behavior depended most strongly on behavioral intentions and on belief in control. Behavioral intentions depended most strongly on existential guilt. This effect accords to previous existential guilt research. Ethnicity and education were considered as privileges in Study II. Privileged Paraguayan students (N = 80) were confronted with the disadvantageous living conditions of Indians and Campesinos. They were asked to appraise the situation. Behavioral intentions and appeal to authorities directed at improving the living conditions of Indians and Campesinos served as criteria. As in Study I, existential guilt was the strongest predictor of behavioral intentions. Study II revealed the role of values in the process of existential guilt and prosocial behavior. This is a new research finding. Indirect effects of the two values of universalism and benevolence on behavioral intentions were obtained. The effect of universalism was mediated by existential guilt and moral outrage, the effect of benevolence was mediated by injustice and existential guilt. Tradition had a negative indirect effect on behavioral intentions. This effect was mediated by justification of deprivation and probably means that adherence to tradition eases the justification of traditionally existing social inequalities in a society.